Abstract:
The development of new, non-invasive approaches for the treatment of tumors has led to the emergence of oncolytic virus therapy. Viruses have been engineered to preferentially target tumor cells. The efficiency and safety of this cancer treatment is dependent upon selective viral replication within cancer cells. In order for viral oncolysis to be successful in the clinical setting, the biodistribution of viral replication must be quantified. This study has used an enzyme-based positron emission tomography (PET) reporter system to trace the viral replication of herpes simplex virus (HSV)-l. [¹⁸F]FHBG was used as the substrate for the HSV-1 enzyme product - thymidine kinase (TK) - in order for PET imaging technique to identity sites of HSV-1 TK activity.
For the full publication click here http://dspace.mit.edu/handle/1721.1/41693
